What you need to know about Indonesia’s vaccine development

first_imgAs Indonesia struggles to contain the COVID-19 epidemic, the country, like many others, is pinning its hopes on vaccine development.Indonesia is looking to secure access to candidate vaccines, with its diplomats and local companies seeking cooperation with producers such as Sinovac Biotech of China and Genexine Inc. of South Korea, as well as the Bill Gates-backed Coalition for Epidemic Preparedness Innovations (CEPI).Meanwhile, for a longer-term, self-sufficient strategy, a national consortium under the Research and Technology Ministry is working on developing its own vaccine, helmed by the Eijkman Institute for Molecular Biology. The vaccine will be named after Indonesia’s flag colors, Merah Putih, or red and white. Kusnandi said the previous first two stages of trials showed a few minor side effects, such as swelling and pain in the injection area as well as fever. All volunteers in the phase III trials, therefore, would be insured so that they could receive free treatment if they were to develop complaints, he said. Kusnandi said the vaccine would be gradually given to all the subjects, estimating 25 subjects per day for five days a week at each of the six trial centers.Read also: Indonesian COVID-19 vaccines to undergo strict human, animal testingBio Farma said it was expecting the preliminary results of the clinical trials to be submitted for emergency use authorization by the Indonesian Food and Drug Monitoring Agency (BPOM) by the first quarter of 2021. Topics : He was referring to the process of producing recombinant proteins by isolating genes of the spike protein and nucleocapsid protein and inserting them into mammalian cells. The team, comprising around 10 young researchers, is now waiting for the cells to reproduce the recombinant proteins, which might take two months, before isolating, purifying and testing the proteins on animals. The Merah Putih vaccine, meanwhile, is a recombinant vaccine. It is a type that “includes only the components, or antigens, that best stimulate the immune system” that can make vaccines safer and minimize side effects, according to the United States’ National Institute of Allergy and Infectious Diseases. The clinical trial research team leader, Unpad professor Kusnandi Rusmil, told The Jakarta Post that about 500 people had applied for the trials, which involve at least 30 doctors and 20 specialist doctors. The vaccines under development mentioned fall into different types. The Merah Putih vaccine, Amin said, was expected to cover at least 50 percent of Indonesia’s vaccine needs, given the country’s large population. The Sinovac vaccine is an inactivated virus vaccine, a traditional category of vaccines which consists of entire pathogens that have been killed with chemicals, heat or radiation. Hence, this type cannot cause diseases but still has antigens to elicit an immune response, experts said. Should the applicants pass the administrative and other preliminary procedures, the team will administer them with the first dose of the experimental vaccine or a placebo, and then a second dose of the vaccine 14 days later. What vaccine types will be offered? Bio Farma and Unpad are now recruiting 1,620 volunteers — all of whom must be healthy adults between the age of 18 and 59 years old with no history of having contracted COVID-19 — to participate in the clinical trials. The team is making a vaccine specifically for the virus strain spread in Indonesia, which, according to Amin, has similarities to the strain circulating around Asia. The company said it would produce 40 million doses for the first batch of vaccine, but the number would increase gradually as the company aims to see its production capacity reach 250 million doses per year by the end of this year. Indonesia is launching the phase III trials — the last stage of clinical testing in humans during which the vaccine is given to thousands of people to confirm and expand results on safety and efficacy from phase I and II trials — along with several countries like Brazil and Bangladesh. The Genexine vaccine is a DNA vaccine which will also be administered twice. According to the WHO, this type of vaccine is a rather new invention that offers “potential advantages over traditional approaches”, such as improved vaccine stability and the absence of any infectious agents. The Sinovac phase III clinical trials in Bandung are to run for six months. As for the Merah Putih vaccine, Eijkman director Amin Soebandrio said his team was now entering the “critical” process that would “determine the success of the vaccine in the future”. All of these attempts are progressing at different paces, while also offering various timelines, production targets and types of vaccines. But they are expected to complement each other, given the broad need to cover Indonesia’s large population of some 270 million people.How is the progress so far?State-owned pharmaceutical company PT Bio Farma has partnered with Sinovac, with the former soon to be launching phase III clinical trials in humans of a Sinovac vaccine alongside Padjadjaran University (Unpad) in Bandung, West Java.It is one of 26 candidate vaccines that are in clinical evaluation according to a compilation made by the World Health Organization (WHO) on July 31. There are 139 candidate vaccines in preclinical evaluation. Bio Farma is also deliberating a contract with the Bill Gates-backed CEPI, with no decision yet made on the number of vaccines that it would “fill and finish” during the manufacturing process, Bio Farma’s R&D project integration manager Neni Nurainy told the Post.Read also: Indonesia teams up with global manufacturers in vaccine huntMeanwhile, homegrown health giant Kalbe Farma is cooperating with Genexine for the trials of Genexine’s DNA vaccine GX-19. Indonesia is expected to run phase II clinical trials for the potential vaccine in September or October, continuing from the phase I trials underway in South Korea until August. What are the timelines and production targets? This vaccine must be injected twice to develop immunity. The government, meanwhile, has given Eijkman 12 months starting from April to develop vaccine prototypes that have been tested on animals, to be given to Bio Farma for clinical trials. Bio Farma aims to mass-produce the vaccine by 2022 after earning approval from the BPOM.last_img read more

Portuguese funds see returns fall as debt allocation struggles

first_imgPerformance figures were submitted by so-called ‘closed’ funds, which are generally pension plans for a single employer or group of companies, and which make up the vast bulk of occupational plans.The WTW universe covers around €13bn in assets, which is 80% of the closed pension fund market in Portugal. It incorporates more than 100 pension funds within the figures to end-December 2016, including the five biggest pension fund managers in Portugal.The figures are based on median performance over each timeframe.The final quarter of the year had produced returns which – at 0.6% – dipped below the previous quarter’s, of 1.4%.Guedes said: “The Portuguese pension fund market has a euro bond exposure of roughly 60%. The fourth quarter was poor for euro bonds in general, and slightly worse for eurozone government aggregate bonds. Another factor in these low returns was probably the high exposure to direct real estate and liquidity, giving a significant ‘cash drag’ effect.”He also highlighted the bias normally found in using local asset managers for local assets: “It’s probably worth noting that the PSI 20 [the top 20 stocks on the Lisbon Stock Exchange] had a painful performance, losing 12% over 2016.”According to regulator ASF, debt was still the single biggest asset in Portuguese pension fund portfolios, with 49% invested directly in the asset class as at end-December 2016. Of this, 31% was in public and 18% in private debt.Direct equity holdings were 8% of portfolios, while direct real estate made up 8%. A further 7% was in cash.In addition, investment funds formed 29% of portfolios, but the split between asset classes was not published.However, estimates from the Portuguese Association of Investment Funds, Pension Funds and Asset Management (APFIPP) broke down the investment fund figures to give an overall asset allocation of 57% in debt, 21% in equities and 13% in real estate.The APFIPP sample covered 87% of the Portuguese pension fund market.Guedes said: “The star of 2016 was definitely the US stock market, mostly due to the ‘Trump effect’ which pushed stock prices through the roof during the fourth quarter of 2016. Given the relatively conservative allocation of the closed pension funds market, the gains arising from the strong performers for 2016 (US, China and oil-driven commodities), were somewhat limited in Portuguese portfolios.” Occupational pension funds in Portugal made an average 1.8% investment return for the 2016 calendar year, down from 3.3% for 2015, according to Willis Towers Watson (WTW).The figures brought average annualised returns for the three years to 31 December 2016 to 4.3%, and for the five years to that date, to 5.8%.Gaudêncio Guedes, an investment consultant at WTW, said: “From the general performance indices, we would have expected around a 4% return overall – excluding real estate – for 2016, if we consider the actual asset allocation of the closed pension funds.“However, the first quarter of 2016 was a tough one for financial markets and it may well have triggered a number of difficult decisions by managers regarding the investment strategies to be adopted that set the path for the rest of the year.”last_img read more

Luxurious coastal inspired dream

first_imgThe living room flows to a deck outdoors. More from newsParks and wildlife the new lust-haves post coronavirus13 hours agoNoosa’s best beachfront penthouse is about to hit the market13 hours agoThere is a fireplace for the cooler months.“It has got a long list of inclusions which you would expect in a forever home,” Mrs Bott said.“It’s got a big shed, which was important to Clint, and a built-in outdoor kitchen and surround sound in the entertainment area.”The layout of the house was designed for family living, with three bedrooms, two bathrooms and a retreat upstairs. The kitchen and dining has plenty of cupboard space.“We wanted it to be a forever family home with a timeless design, but also built for outdoor entertaining to suit the Queensland lifestyle,” Mrs Bott said.From conception to handing over the keys, the build at 15 Elaroo St took about seven months, and the family have enjoyed living in the house ever since. The deck overlooks the pool.Downstairs are two more bedrooms, a third bathroom with a separate toilet, study, rumpus, laundry and open-plan kitchen, living and dining room.It’s this open-plan area that is one of Mrs Bott’s favourite spaces.“My favourite thing about the house is all the living areas are really well connected,” she said.“If you are in the kitchen, you can see out to the deck, over the pool and to the pool house, which is really important when you have a young family.” It is even big enough for a more casual area to kick back.The Botts have two children, Oliver, 5, and Charlie, 3, and Mrs Bott said the layout of the house had functioned as intended.“The open-plan feel definitely provides excellent communication with the family and we can be in different spaces but still communicate.” The facade is dreamy.Inspired by the coastal homes of the east coast of America, this Morningside beauty is a dream home.Clare and Clinton Bott designed their forever home, with help from a draftsman, about three years ago. The pool house.Mrs Bott loved entertaining at the house, and enjoyed its proximity to Oxford St and schools.The house is being marketed by Tony O’Doherty of Belle Property Bulimba.Video Player is loading.Play VideoPlayNext playlist itemMuteCurrent Time 0:00/Duration 0:51Loaded: 0%Stream Type LIVESeek to live, currently playing liveLIVERemaining Time -0:51 Playback Rate1xChaptersChaptersDescriptionsdescriptions off, selectedCaptionscaptions settings, opens captions settings dialogcaptions off, selectedQuality Levels720p720pHD576p576p432p432p270p270pAutoA, selectedAudio Tracken (Main), selectedFullscreenThis is a modal window.Beginning of dialog window. Escape will cancel and close the window.TextColorWhiteBlackRedGreenBlueYellowMagentaCyanTransparencyOpaqueSemi-TransparentBackgroundColorBlackWhiteRedGreenBlueYellowMagentaCyanTransparencyOpaqueSemi-TransparentTransparentWindowColorBlackWhiteRedGreenBlueYellowMagentaCyanTransparencyTransparentSemi-TransparentOpaqueFont Size50%75%100%125%150%175%200%300%400%Text Edge StyleNoneRaisedDepressedUniformDropshadowFont FamilyProportional Sans-SerifMonospace Sans-SerifProportional SerifMonospace SerifCasualScriptSmall CapsReset restore all settings to the default valuesDoneClose Modal DialogEnd of dialog window.This is a modal window. This modal can be closed by pressing the Escape key or activating the close button.Close Modal DialogThis is a modal window. This modal can be closed by pressing the Escape key or activating the close button.PlayMuteCurrent Time 0:00/Duration 0:00Loaded: 0%Stream Type LIVESeek to live, currently playing liveLIVERemaining Time -0:00 Playback Rate1xFullscreenStarting your hunt for a dream home00:51last_img read more

Dinagyang ‘rest day’ for students tomorrow

first_img* Iloilo Science and TechnologyUniversity (ISAT) University – Iloilo City campus ILOILO City – Tomorrow there will be noclasses (preschool, elementary, high school and senior high school levels) inboth public and private schools here. This will give students participating inthe Dinagyang Festival highlight today – the ati tribes competition – a day of rest, said Mayor Jerry Treñas. According to Treñas, Jan. 27 would be abusy day for the city government to clean the downtown area – the epicenter ofthe Dinagyang celebration. Suspending classes would ease traffic congestiondowntown, thus making the work of people task to clean the area easier, heexplained. For tertiary (college level) schools, hegave their administrators the discretion to decide. * West Visayas State University (WVSU) LaPaz campus Taking cue from the mayor, severalcolleges and universities here announced the suspension of Monday’s classes,too. These schools were the following: * St. Therese-MTC Colleges (both inMagdalo, La Paz district and La Fiesta site in Molo district)/PN * St. Paul University Iloilo * University of San Agustin * PHINMA University of Iloilolast_img read more

Area youth wins Grand Champion Meat Chicken at State Fair

first_imgIndianapolis, IN — Congratulations to Franklin County’s Braylon Dorrel for winning Grand Champion Meat Chicken at the 2020 Indiana State Fair 4-H Showcase. If your 4-H project did well at the State Fair, let us know by sending an email to news@wrbiradio.com.last_img

Gabriela Knutson steps up in 1st match, guides Syracuse to win against Columbia

first_img Published on January 29, 2016 at 8:01 pm Contact Chris: cplucey@syr.edu Gabriela Knutson dropped her racket and let out a shriek as she saw her volley go into the net and double match point slip through her fingers near the end of her second-set victory.The freshman won both her singles and doubles matches in her Syracuse (1-0) debut against Columbia (1-2) on Friday afternoon, helping SU get a win against the Lions. Still, in that instant, Knutson was concerned, but not because of her play. She was on the verge of fainting on the court.“I was panicking,” Knutson said of when she returned to the court, after getting sick in the Syracuse locker room. “If I lose this point, I’ll have to play more games and I’ll probably collapse … I gotta get this.”Knutson returned to the baseline and served match point almost immediately. The shot was an ace, right down the midline on the service box. Knutson won 6-3, 6-4.The winning shot against her singles opponent, Star Makarome, punctuated a debut marked by Knutson’s powerful groundstrokes and aggressive style of play.AdvertisementThis is placeholder textDuring her doubles match, Knutson was on the attack. Dina Hegab — another freshman — was her partner in the number two spot of the lineup, and spent the majority of their match on the baseline. Knutson finished points at the service line with her flat, searing forehand.The freshman charged the net so aggressively on one point of the 6-2 win that she didn’t give herself the time to react to her opponents return, and was hit in the stomach by the shot when it came over the net.“I’ve played that way since I was a little girl,” Knutson said. “That’s my game, ripping it. I got hit in the belly once but we won… I got back at her for that.”However, near the end of the second set of her singles match in the third spot against Makarome, Knutson realized that power alone wouldn’t be the difference.Her opponent, weary of trying to match Knutson’s power, began to return with high, arcing shots in order to keep her off balance on the baseline. Knutson adjusted quickly, mixing her blistering pace with spin and drop shots to keep her opponent at bay.“I had to start creating a bit more motion,” Knutson said. “More short balls and spin. In the end, the variety made me better than her.”That brought Knutson to the “return and volley,” which she used to break serve and go up, 5-4, in the second set.On break point, Knutson brought pace on the first hit and then drew Makarome to the service line as she followed her shot. From there, Knutson went up the line for the winning hit.Knutson recalled SU head coach Younes Limam telling her and other players not to be nervous before the game, but that was never a problem for the freshman.And her performance Friday proved to be a source of even more confidence.“She stepped up, as a freshman,” Limam said, “and played some really good tennis.” Comments Facebook Twitter Google+last_img read more

Courtney Brosnan’s career day leads Syracuse women’s soccer to shocking tie with No. 2 Florida State

first_img Facebook Twitter Google+ Courtney Brosnan frantically jumped up and down, shouting “clear the ball already” to her teammates. Only one minute remained in overtime against Florida State. Brosnan had already faced 27 shots from FSU, eight of which came in overtime.But instead of displaying exhaustion, she appeared animated and lively.Defender Maddie Iozzi complied with Brosnan’s demand and booted the ball to the other end of the field. FSU’s final assault on the Orange was terminated.When the horn sounded, Brosnan leapt into the air as her teammates mobbed her. Her intense demeanor throughout the game changed as a huge smile crept across her face.Brosnan compiled a career-high 15 saves in the best performance of her career. It even reminded Syracuse head coach Phil Wheddon of Tim Howard’s performance against Belgium in the 2014 FIFA World Cup for the United States. Brosnan was nearly unbeatable, letting up just one goal in the game. It was the second-most saves in a game in program history.AdvertisementThis is placeholder textSyracuse (7-5-3, 0-4-2 Atlantic Coast) faced an attacking onslaught from No. 2 Florida State (9-2-2, 3-1-2) throughout the game. Most of it was spent in the Orange’s half — save for a few counterattacks — as SU essentially parked the bus on defense, keeping all but one player in the defensive end except on counterattacks. FSU outshot the Orange 27-9 on the day, but Brosnan held the Seminoles to one goal en route to a shocking 1-1 tie.Florida State was coming off a 2-1 upset by Boston College three days earlier.“She’s been amazing for us all year,” Wheddon said. “But for her to come up big like that — especially when she’s injured — is a massive boost for us.”Jacob Greenfeld | Asst. Photo Editor Ironically in her career-best performance, Brosnan was a game-time decision after separating her shoulder Thursday against Virginia Tech.She didn’t train on Friday or Saturday. The first action she received since Thursday, according to Wheddon, was a little handling practice Saturday morning.“Since Virginia Tech, I’ve been taking care of it and icing it as much as possible,” Brosnan said. “I came out in the warm up and I just knew I was ready to play. Pain is relative but it obviously hurt throughout.”Coming into Saturday’s game, Syracuse had scored only one goal in its last four games. It took just 59 seconds for the Orange to erase that trend.Alex Lamontagne received a crisp pass from Stephanie Skilton shortly after kickoff. Despite being 30 yards away from goal, Lamontagne curved the ball high over FSU goalie Cassie Miller and into the net.But Florida State then controlled possession and relentlessly pressed forward. In the fifth minute, midfielder Megan Connolly laid a perfect cross to fellow sophomore Kaycie Tillman. Tillman booted it past Brosnan but the referee immediately ruled she was offside.Yet it seemed inevitable that one of the Seminoles’ overwhelming number of chances would succeed. Finally, in the 25th minute, Connolly pushed on a counterattack following an Eva Gordon turnover. She passed it to midfielder Elin Jensen, who settled the ball, dribbled it to her left, and rocketed it over Brosnan to tie the game up.That was the only time Florida State beat Brosnan, though.The rest of the game consisted of the same. There were repeated and relentless Seminoles attacks against the Syracuse defense. Once in a while, Syracuse conjured powerful counterattacks and got opportunities on net, but they were few and far between.“That kinda wasn’t the strategy,” Jessica Vigna said with a laugh, regarding the prospect of the team parking the bus. “But it got difficult, so especially in the second half so we were just like OK, let’s survive until the end.”“It depended on which end we were going to defend first in overtime,” Wheddon said. “We had the wind in our face for the first overtime so we just tried to weather the storm on defense, and we knew we could catch them on the counter.”Despite dropping most of its team in front of the net, Syracuse still allowed a barrage of shots Brosnan’s way.In the second overtime, Brosnan slid to her knees to knock away a one-on-one shot from Tillman with her hands. Taylor Hallmon collected the rebound, but Brosnan dove to stop another potential game-winning shot.Wheddon’s stock answer describing Brosnan’s performances this season has been that she’s one of the best goalkeepers in the ACC.He has said it at least four times now.But her outing Sunday wasn’t just another good performance. It was her best. Commentscenter_img Published on October 9, 2016 at 8:02 pm Contact Byron: brtollef@syr.edulast_img read more

Clonmel Celtic advance to last four of the FAI Junior Cup

first_imgClonmel Celtic have reached the last four of the FAI Junior Cup. They ran out comfortable winners in their game against City United of Sligo this afternoon. The full time score was Clonmel Celtic 2 City United 0, with goals from David Joyce and Sean O’Hara. Ronan Quirke was at the match for Tipp FM Sport, with the Tipp club going in at half time a goal ahead.  Clonmel Celtic’s joint manager Karl Condon praised his side’s defensive effort.last_img

Tandoh Hails New Asoju Oba Champions

first_imgKunle AdewaleThe Chairman of Lagos State Sports Commission, Dr Kweku Tandoh has hailed the new champion in the Men’s Singles of Asoju Oba Table Tennis Championship, saying that his victory has further proved that the state is on course in its developmental programmes.The 50th edition of the Asoju Oba Table Tennis Molade Okoya-Thomas Championship ended at the Teslim Balogun Stadium, Surulere on Friday with David Fayele, who can be regarded as a local boy, taking the shine off Europe-based Olajide Omotayo in the final that ended 4-2. Fayele of the Nigerian Army was presented with the star prize of the competition, a brand new car courtesy of the family of the late Sir Molade Okoya-Thomas, the sponsor of the oldest running competition in Nigeria.To Tandoh, Fayele defeating an experienced Omotayo who is based abroad was a testimony that Lagos is a breeding ground for upcoming talents, who would take over from the ageing athletes very soon.He said Fayele will be one of the several youngsters Team Lagos will parade at the 19th National Sports Festival, which holds in Abuja from 6-16 December, adding that the commission would leave nothing to chance to ensure Team Lagos have good outing in Abuja.Reacting to his victory over Omotayo, the new champion said that he was able to overcome the challenge of his opponent with determination and focus.“When I discovered that I would be playing Omotayo who is based abroad, I had to double up my training and as a soldier, I have this strong belief that a civilian cannot defeat a soldier in any contest. I want to assure that I will repeat this feat at the Sports Festival in Abuja,” said Fayele, who won the mixed double event with Nimota Aregebsola.In the women’s singles, Bose Odusanya defeated Aregesola in a game that ended 4-2. Odusanya was also a proud owner of a brand new car.Share this:FacebookRedditTwitterPrintPinterestEmailWhatsAppSkypeLinkedInTumblrPocketTelegramlast_img read more

Draw match between FC ”Široki Brijeg” i FC ” Žalgiris”

first_imgPlayers of FC ”Široki Brijeg” went to Novigrad, where they will participate at the Istria Winter Cup, and FC ”Željezničar” will also participate at the Cup.FC ”Široki Brijeg’’ played yesterday its first match against the first team of Lithuania FC  ”Žalgiris” which ended in a result 0:0.Tournament will last until 10 February, and in the group with FC ”Široki Brijeg” there is also FC ”Gyor” from Hungary and FC ”Wolsberger” from Austria.last_img